Award
National Cancer Institute 5P01CA272222-03
Microscale Radionuclide S-values for αRPT
Recipient
Johns Hopkins University
Award Amount
$321,148.00
Ceiling
$321,148.00
Awarded
September 04, 2025
Identifier
5P01CA272222-03
This award funds a project to develop microscale radionuclide S-values for alpha-particle radiopharmaceutical therapy to improve tissue-level dosimetry in cancer treatment, involving modeling and validation in humans and animal models.
Description
Radiopharmaceutical therapy with alpha-particle emitters (αRPT) provides a unique and effective treatment for cancer in its advanced stages. The project aims to develop microscale radionuclide S-values to enable tissue-level dosimetry assessment in individual patients, supporting targeted alpha therapy in organs such as bone marrow, kidneys, liver, lungs, salivary glands, lacrimal glands, and small intestine.