Award
NIH Reporter #5R01AI107779-10
Chromosome 17q21, allergic inflammation, and remodeling
Recipient
University of California, San Diego, La Jolla, CA
Award Amount
$558,606.00
Ceiling
$558,606.00
Awarded
February 28, 2024
Identifier
5R01AI107779-10
Research project studying the role of gene ORMDL3 in asthma development and allergic inflammation, using transgenic mice and genomic techniques to identify therapeutic targets.
Description
The project focuses on the gene ORMDL3 on chromosome 17q21, linked to human asthma. It aims to understand how ORMDL3 influences CD4+ T cell function, allergic inflammation, and asthma using transgenic mice, proteomic and RNA sequencing approaches, and single base editing to study SNPs linked to ORMDL3.