Award
NIH Reporter #5K43TW011995-05
Influence of fluoxetine on the disposition kinetics of dolutegravir among people living with HIV with major depression in Nigeria
Recipient
College of Medicine, University of Ibadan, Nigeria
Award Amount
$73,676.00
Ceiling
$73,676.00
Awarded
August 10, 2026
Identifier
5K43TW011995-05
A research project investigating the impact of fluoxetine on dolutegravir pharmacokinetics and safety among HIV patients with major depression in Nigeria to improve HIV treatment outcomes in the U.S.
Description
This study will determine whether fluoxetine, a widely used antidepressant, influences the effectiveness of dolutegravir-based HIV treatment among people living with HIV (PLWH) with major depression in Nigeria. The findings aim to optimize antiretroviral therapy, enhance treatment safety, inform HIV care practices, and support improved long-term health outcomes for PLWH in the U.S.