Award
NIH Reporter #5R01HL164415-04
Rescue of Autoimmune-Associated Long QT Syndrome by Decoy Peptides
Recipient
NARROWS INSTITUTE FOR BIOMEDICAL RES INC
Award Amount
$538,891.00
Ceiling
$538,891.00
Awarded
August 12, 2025
Identifier
5R01HL164415-04
This award funds research to develop decoy peptides to treat autoimmune-associated Long QT Syndrome by neutralizing specific antibodies and studying electrophysiological effects, aiming to create innovative therapies for cardiac arrhythmias.
Description
The project focuses on developing decoy peptides to neutralize anti-Ro antibodies associated with Long QT Syndrome. The research aims to validate the cross-reactive epitope hypothesis, normalize QTc prolongation in animal models, and investigate electrophysiological mechanisms. The project emphasizes innovative therapeutic tools for autoimmune-related cardiac arrhythmias.