Award
National Institute of General Medical Sciences 5R35GM131732-08
ER and post-ER quality control of integral membrane proteins
Recipient
University of Pittsburgh at Pittsburgh, PA, USA
Award Amount
$394,966.00
Ceiling
$394,966.00
Awarded
May 08, 2026
Identifier
5R35GM131732-08
NIH grant awarded to University of Pittsburgh to study ER and post-ER quality control of integral membrane proteins, focusing on ERAD pathways and misfolded protein handling with a funding amount of $394,966 for 2026.
Description
This NIH research grant focuses on understanding the quality control mechanisms of integral membrane proteins in the endoplasmic reticulum (ER) and post-ER, specifically addressing how misfolded proteins are handled and destroyed to prevent toxic accumulation. The project aims to dissect molecular mechanisms of ER-associated degradation (ERAD), investigate aggregation-prone membrane proteins, and identify disease-associated ERAD substrates using innovative tools and computational-experimental pipelines.