NIH Reporter #7R01DA038964-10

Biasing Mu Opioid Receptor Signaling in vivo

This award funds research to develop and understand new opioid drugs that provide pain relief without the common side effect of respiratory suppression by targeting the mu opioid receptor differently than traditional opioids.

Description

The project aims to understand the signaling mechanisms of mu opioid receptor agonists and develop therapeutics with fewer side effects. The research involves biochemical studies, receptor binding analysis, and pharmacological profiling conducted at the University of South Florida. The goal is to develop new drugs that act differently at the mu opioid receptor to provide pain relief without respiratory suppression, a primary cause of opioid overdose.

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