Award
NIH Reporter #7R01MH129558-04
A Confirmatory Efficacy Trial of Engaging a Novel Sleep/Circadian Rhythm Target as Treatment for Depression in Adolescents
Recipient
National Institute of Mental Health (NIMH)
Award Amount
$778,871.00
Ceiling
$778,871.00
Awarded
April 10, 2026
Identifier
7R01MH129558-04
A randomized controlled trial funded by NIH to evaluate a behavioral sleep intervention for adolescents with depression and evening circadian preference, aiming to improve depression outcomes by targeting circadian rhythm.
Description
This project involves a confirmatory efficacy trial to test the hypothesis that improving the relationship between biological circadian timing and waketime can improve depression outcomes in adolescents with Major Depressive Disorder (MDD) and evening circadian preference (ECP). The study will be a randomized controlled trial with 200 adolescents, comparing a behavioral sleep intervention (TranS-C) to psychoeducation. The project is funded by the NIH and is scheduled for a fiscal year 2026-2027.