Award
National Institute of Allergy and Infectious Diseases 1R01AI198973-01
IgG4-galactosylation as a pathogenic post-translational modification in IgG4-mediated autoimmunity
Recipient
Massachusetts General Hospital, Boston, MA, United States
Award Amount
$834,190.00
Ceiling
$834,190.00
Awarded
July 15, 2026
Identifier
1R01AI198973-01
NIH funded research project investigating the role of IgG4 glycosylation in autoimmune diseases to identify biomarkers and develop targeted therapies.
Description
This research project aims to define the properties of IgG4 antibodies that lead to gain-of-function in autoimmune and inflammatory settings, advancing fundamental immunological knowledge and identifying novel biomarkers for IgG4-related disease, MuSK+ myasthenia gravis, and pemphigus vulgaris. The study investigates a post-translational modification on IgG4 that may contribute to inflammation and disease progression, analyzing patient samples and exploring interactions with Fcγ receptors to develop targeted therapeutics.