Award
National Institute of Allergy and Infectious Diseases 5F32AI191525-02
Revealing the Structural Determinants of TCR Cross-Recognition via Extended Positional Scanning
Recipient
University of Notre Dame
Award Amount
$82,048.00
Ceiling
$82,048.00
Awarded
April 17, 2026
Identifier
5F32AI191525-02
Research project funded by NIAID to develop predictive models for T cell receptor cross-reactivity using extended positional scanning and machine learning to enhance T cell therapy safety and efficacy.
Description
The project aims to develop an extended positional scanning library (ePSL) to generate diverse peptide datasets, leveraging structural modeling and machine learning to understand TCR specificity and cross-recognition. The goal is to create predictive models for TCR recognition of diverse peptides, improving safety and efficacy of T cell therapies.