Award
National Institute of Neurological Disorders and Stroke 5R01NS136485-02
Identification of novel lead EphB1/2 tyrosine kinase inhibitors targeting peripheral neuropathic pain
Recipient
Texas Tech University Health Sciences Center
Award Amount
$388,400.00
Ceiling
$388,400.00
Awarded
March 23, 2026
Identifier
5R01NS136485-02
This award funds research to develop new small molecule inhibitors targeting EphB1/2 tyrosine kinase to treat peripheral neuropathic pain, aiming to provide non-opioid therapies for chronic pain management.
Description
The project aims to develop small molecule inhibitors targeting EphB1/2 tyrosine kinase to mitigate peripheral neuropathic pain, a severe condition often treated with opioids. The research goals include developing novel EphB1/2 tyrosine kinase inhibitors and elucidating their molecular mechanisms in mitigating neuropathic pain in vivo.