Award
National Heart, Lung, and Blood Institute 5K08HL159289-05
Engineered microsystems to assess endothelial contribution to myeloproliferative neoplasm thrombosis
Recipient
University of Minnesota, Minneapolis, MN
Award Amount
$171,180.00
Ceiling
$171,180.00
Awarded
July 31, 2026
Identifier
5K08HL159289-05
Award for research on endothelial contributions to thrombosis in MPNs using engineered microsystems and microfluidic models to study cellular interactions and signaling pathways.
Description
This project aims to elucidate mechanisms of thrombosis in myeloproliferative neoplasms (MPNs) related to endothelial cell activation and signaling pathways, potentially informing targeted therapies. It involves using endothelialized microfluidics models to study the effects of the JAK2V617F mutation on endothelial cell pro-coagulant and adhesive functions under physiologic shear conditions and exploring Gas6-Axl-MERTK signaling in pro-thrombotic activation.