Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK136512-03
The role of serpins and LRP1 in the esophageal epithelium during eosinophilic esophagitis
Recipient
Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States
Award Amount
$563,828.00
Ceiling
$563,828.00
Awarded
June 03, 2026
Identifier
5R01DK136512-03
NIH grant awarded to study the role of serpins and LRP1 in eosinophilic esophagitis, focusing on inflammation resolution and epithelial homeostasis to develop targeted therapies.
Description
This project investigates the role of serpins and LRP1 in promoting inflammatory resolution and epithelial homeostasis in eosinophilic esophagitis (EoE), aiming to elucidate mechanisms of LRP1 processing and its impact on gene transcription changes that propagate EoE, with the goal of developing targeted therapies.