Award
National Institute of Allergy and Infectious Diseases 5K99AI182422-02
Structural and Functional Alteration of host RBCs by Babesia
Recipient
New York Blood Center, New York, NY, United States
Award Amount
$134,730.00
Ceiling
$134,730.00
Awarded
December 02, 2025
Identifier
5K99AI182422-02
NIH research grant awarded to study how Babesia parasites alter host red blood cells, aiming to identify molecular mechanisms and potential therapeutic targets.
Description
This project aims to elucidate the mechanisms of RBC remodeling by Babesia parasites, focusing on the export of specific proteins, including proteases, and their interactions with host cell cytoskeletal proteins. The research involves morphological, rheological, and biophysical analyses, as well as molecular characterization of parasite proteases. The goal is to identify targets for novel chemotherapeutics and advance understanding of host-parasite interactions.