Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK138025-03
microRNA-controlled mRNA therapeutics
Recipient
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY, UNITED STATES
Award Amount
$559,205.00
Ceiling
$559,205.00
Awarded
January 16, 2026
Identifier
5R01DK138025-03
This award funds research to develop modRNA therapeutics with cell-specific expression control using miRNA target sites to tailor immune responses, potentially improving vaccine efficacy and tolerance.
Description
The goal of this project is to establish novel modRNA formulations that tailor expression of proteins to specific cell types and determine how expression in specific cells directs immunity to modRNA-encoded protein. The project aims to generate and test miRT for silencing modRNA in different cell types, including endothelium and myocytes, to influence immune response and vaccine efficacy. It leverages technology for cell-specific silencing of RNA to control modRNA expression and study immune outcomes.