Award
National Institute on Aging 1R21AG102223-01
Roles of Misfolded Protein Aggregates on Latent Reservoirs in SIV-infected, ART-treated Aged Rhesus Macaques
Recipient
University of Nebraska Medical Center
Award Amount
$422,125.00
Ceiling
$422,125.00
Awarded
May 19, 2026
Identifier
1R21AG102223-01
Research project funded by the National Institute on Aging to study the effects of misfolded protein aggregates on HIV reservoirs and neurodegeneration in aged rhesus macaques, aiming to inform HIV cure strategies and Alzheimer's disease understanding.
Description
The project investigates how aging-related amyloid accumulation affects HIV reservoirs and how HIV infection and ART may accelerate Alzheimer’s disease (AD/ADRD). Using aged, SIV-infected, cART-treated rhesus macaques, the study explores the intersection of HIV, neurodegeneration, and aging. It aims to study the impact of amyloid fibril deposition on HIV reservoirs and assess how viral infection influences aging-associated amyloidosis and AD-ADRD development.