Award
National Cancer Institute 1R01CA307676-01A1
Mechanisms and Functional Roles of PARP1 Hyperactivation in Cancer
Recipient
University of California-Irvine
Award Amount
$639,707.00
Ceiling
$639,707.00
Awarded
June 26, 2026
Identifier
1R01CA307676-01A1
NIH awarded a research grant to University of California-Irvine to study the mechanisms of PARP1 hyperactivation in cancer, focusing on DNA damage response and the interaction of ATR inhibitors and PARP inhibitors.
Description
This NIH research grant focuses on understanding the mechanisms by which ATR inhibitors enhance cancer cell sensitivity to PARP inhibitors, particularly through DNA replication fork cleavage by APE1 and regulation of PARP1 activation. The project aims to elucidate the role of ATR kinase, PARP1, and APE1 in DNA damage response and cancer biology.