Award
NIH Reporter #1K99AG100394-01
LRRK2-associated mechanisms of granulovacuolar degeneration body formation in neurodegenerative diseases
Recipient
Duke University, Durham, NC
Award Amount
$112,406.00
Ceiling
$112,406.00
Awarded
September 11, 2026
Identifier
1K99AG100394-01
This NIH R01 grant funded by the National Institute on Aging supports research on LRRK2-associated pathways in neurodegenerative diseases, focusing on granulovacuolar degeneration bodies and potential therapeutic targets.
Description
The project aims to investigate the role of LRRK2-associated pathways in granulovacuolar degeneration bodies (GVBs) and their impact on neurodegeneration. The research involves labeling GVBs, identifying their proteome, and testing the role of LRRK2 and Rab12 in GVB formation and activity. The study will also explore lysosomal mechanisms and potential therapeutic targets.