Award
National Institute of Allergy and Infectious Diseases 5P01AI097113-14
Infections and the Stability of Transplantation Tolerance
Recipient
University of Chicago, Chicago, IL, United States
Award Amount
$2,017,948.00
Ceiling
$2,017,948.00
Awarded
May 04, 2026
Identifier
5P01AI097113-14
The project investigates mechanisms of T cell dysfunction and strategies to overcome barriers to transplantation tolerance, aiming for lifelong graft acceptance without global immunosuppression, especially during infections.
Description
This project addresses the barriers to induction and maintenance of transplantation tolerance, exploring solutions leveraging pregnancy-induced immune tolerance and chronic antigen exposure.