Award
NIH Reporter #1R01DC023588-01
Understanding the logic of mitral/tufted cell projections using DNA barcoding and odor response profiling
Recipient
Cold Spring Harbor Laboratory
Award Amount
$957,448.00
Ceiling
$957,448.00
Awarded
August 28, 2026
Identifier
1R01DC023588-01
The award supports research to map and understand the structured connectivity of olfactory bulb output neurons and their projections using DNA barcoding and odor response profiling, aiming to reveal neural algorithms underlying olfactory processing.
Description
This project investigates the functional properties and logic of long-range projections between odorant receptors, individual olfactory bulb output neurons, and the olfactory cortex using a novel high-throughput DNA barcoding method combined with odor response profiling. The research aims to uncover the anatomical and functional organization of the mammalian olfactory system with single-neuron resolution, challenging the prevailing model of random connectivity in olfaction.