Award
NIH Reporter #1R01NS146933-01A1
Pericyte phenotypic switching in diabetic post-stroke cognitive impairment (PSCI)
Recipient
Oregon Health & Science University
Award Amount
$594,435.00
Ceiling
$594,435.00
Awarded
August 14, 2026
Identifier
1R01NS146933-01A1
NIH grant awarded to Oregon Health & Science University to study the role of pericyte-microglial interactions in diabetic post-stroke cognitive impairment, aiming to develop therapeutic agents to prevent PSCI.
Description
This NIH grant supports research investigating the mechanisms by which communication between pericytes and microglia under diabetic conditions contributes to post-stroke cognitive impairment (PSCI). The study aims to determine if endothelial-derived epoxyeicosatrienoates (EETs) acting on GPR39 receptors on pericytes protect against PSCI, and whether disruption of this signaling pathway in diabetes exacerbates inflammation and microglial activation.