Award
NIH Reporter #5R16AI177410-03
Role of epigenetic changes in intracellular survival and replication of Legionell pneumophila
Recipient
Western Kentucky University
Award Amount
$176,923.00
Ceiling
$176,923.00
Awarded
August 07, 2026
Identifier
5R16AI177410-03
Research project funded by NIAID to study how epigenetic changes affect the survival and replication of Legionella pneumophila inside host cells, aiming to inform therapeutic and preventive strategies.
Description
This project focuses on the role of epigenetic changes in the intracellular survival and replication of Legionella pneumophila. It aims to elucidate how bacterial nucleomodulins influence host gene expression through DNA methylation and histone modifications, contributing to bacterial pathogenesis.