Award
National Heart, Lung, and Blood Institute 5R01HL171614-03
Cardiac microtubules as regulators of diastolic function.
Recipient
University of Vermont & St. College
Award Amount
$529,558.00
Ceiling
$529,558.00
Awarded
March 20, 2026
Identifier
5R01HL171614-03
Research project funded by the National Heart Lung and Blood Institute to investigate the role of cardiac microtubules in diastolic heart disease, focusing on myocardial stiffness and diastolic function, aiming to develop targeted therapies.
Description
This project aims to determine if cardiac microtubules underlie diastolic dysfunction in diastolic heart disease (DHD). The research explores the stabilization of the cardiac microtubule network by hypertension and metabolic syndrome, and how microtubules regulate myocardial stiffness and diastolic performance. The study uses ex-vivo myocardial preparations to quantify microtubule influence on diastolic function, with the goal of identifying potential microtubule-targeting therapies.