Award
National Cancer Institute 5R01CA257523-05
Effects of inflammaging on intestinal epithelial cells and aspirin chemoprevention.
Recipient
Massachusetts General Hospital, Boston, MA, United States
Award Amount
$904,596.00
Ceiling
$904,596.00
Awarded
May 13, 2025
Identifier
5R01CA257523-05
Research project funded by the National Cancer Institute studying how inflammaging affects intestinal stem cells and aspirin's chemopreventive effects in older adults, aiming to optimize aspirin use and develop biomarkers.
Description
This project investigates the impact of low-dose aspirin (LDA) on colonic epithelium, patient-derived organoids, and urinary prostaglandins in older adults, focusing on inflammaging and its role in colon tumor incidence and progression. The study aims to elucidate biological mechanisms underlying differential effects of LDA in aging populations and develop biomarkers for risk-benefit optimization.