Award
National Institute on Drug Abuse 5DP1DA058385-04
Development of High-Affinity and Selective Ligands as a Pharmacological Tool for the Dopamine D4 Receptor (D4R) Subtype Variants
Recipient
Not specified
Award Amount
$447,000.00
Ceiling
$447,000.00
Awarded
March 23, 2026
Identifier
5DP1DA058385-04
This award funds research to develop selective ligands for dopamine D4 receptor variants to aid in substance use disorder and ADHD treatment.
Description
The project aims to discover candidate medications and develop new molecular tools to study the dopamine D4 receptor (D4R) and its variants, including D4.4R and D4.7R. The research focuses on designing, synthesizing, and evaluating new ligands using computational modeling to develop selective D4R ligands for potential therapeutic use in substance use disorders and ADHD.