Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK139541-03
Structural Mechanisms of Polycystic Kidney Disease Proteins
Recipient
University of Utah, Salt Lake City, UT
Award Amount
$660,667.00
Ceiling
$660,667.00
Awarded
May 05, 2026
Identifier
5R01DK139541-03
This NIH-funded project at the University of Utah focuses on understanding the structure and function of polycystic kidney disease proteins to inform therapeutic strategies for related genetic disorders.
Description
The project aims to elucidate the structural principles and channel properties of polycystic kidney disease proteins, which are the sites of mutations causing autosomal dominant polycystic kidney disease, biliary atresia, and congenital heart defects. The study will determine structures and stoichiometry of various polycystin complexes, define their channel properties, and develop extracellular vesicle-based biomarkers for ADPKD.