Award
National Institute of Allergy and Infectious Diseases 5K08AI183990-02
ENHANCEMENT OF CD4CAR T-CELL PERSISTENCE IN VIVO
Recipient
University of Washington
Award Amount
$186,408.00
Ceiling
$186,408.00
Awarded
August 11, 2025
Identifier
5K08AI183990-02
The award supports research to enhance the persistence and function of HIV-targeting CAR T cells using IL15 cytokine to achieve long-term viral remission, validated in non-human primate models.
Description
This project aims to develop HIV-targeting chimeric antigen receptor (CAR) T cells with enhanced long-term persistence to achieve viral remission in HIV-infected individuals. The research will focus on overcoming soluble antigen inhibition and extending CAR T-cell survival using IL15 cytokine, validated in non-human primate models.