Award
NIH Reporter #5R01AG096179-02
Examining Effects of Intensive BP Control on MCI/Dementia and Plasma Biomarker Trajectories by AD Pathology: Elucidating neuroprotective effects in the SPRINT trial
Recipient
Utah State Higher Education System--University of Utah
Award Amount
$5,003,735.00
Ceiling
$5,003,735.00
Awarded
July 27, 2026
Identifier
5R01AG096179-02
A research project funded by the National Institute on Aging to study the neuroprotective effects of intensive blood pressure control on mild cognitive impairment and dementia, using plasma biomarkers from the SPRINT trial.
Description
This project analyzes longitudinal plasma biomarkers from stored SPRINT samples to assess how baseline Alzheimer's Disease pathology or ε4 modifies the effects of blood pressure control on dementia risk, and how biomarkers change over time and predict dementia. The study aims to refine hypertension treatment strategies to lower dementia risk, identify subgroups for targeted therapies, and create a public resource of biomarker data.