Award
NIH Reporter #1K08AI202375-01
Tissue Macrophage Heterogeneity in Chronic Graft-Versus-Host Disease Fibrosis
Recipient
Fred Hutchinson Cancer Center
Award Amount
$164,376.00
Ceiling
$164,376.00
Awarded
August 18, 2026
Identifier
1K08AI202375-01
This NIH-funded project led by Dr. Julie Renee Boiko at Fred Hutchinson Cancer Center focuses on understanding the heterogeneity of tissue macrophages in chronic graft-versus-host disease fibrosis. It aims to identify macrophage subsets and their interactions to develop targeted therapies for cGVHD, using advanced immunology and genomics techniques.
Description
The project involves defining profibrotic macrophage subsets’ development and tissue interactions to facilitate macrophage-directed therapy for chronic graft-versus-host disease (cGVHD). The research includes animal modeling, basic immunology, and computational genomics including spatial transcriptomics and single cell sequencing. The project aims to improve therapies for patients with fibrotic cGVHD by analyzing how macrophage subsets contribute to disease progression and interact with fibroblasts, using both animal models and human tissue specimen analysis to identify disease stage-specific targets for intervention.