Award
National Cancer Institute 11506149
CAUSE - Connecting DNA Adducts, Unexplained Mutational Signatures, and Cancer Etiologies
Recipient
University of Minnesota
Award Amount
$2,040,633.00
Ceiling
$2,040,633.00
Awarded
July 28, 2026
Identifier
11506149
Award for developing a platform to connect DNA adducts with mutational signatures to understand cancer etiologies, funded by the National Cancer Institute.
Description
This project aims to develop a high-throughput discovery platform to link DNA adducts to mutational signatures, focusing on endogenous, environmental, and chemotherapy-induced DNA damage. The project involves advanced mass spectrometry, structural characterization, genome-wide lesion mapping, and AI modeling. The award is funded by the National Cancer Institute and is part of Cancer Grand Challenges.