National Institute of General Medical Sciences 2R15GM119081-03

Cotranslational control of functional and pathological conformational switching of nascent polypeptides

The award supports research on the cotranslational control of conformational switching in nascent polypeptides, focusing on mechanisms regulating amyloid formation and their implications for protein misfolding disorders. The goal is to understand how cells maintain proteostasis and the physiological significance of conformational switching during protein synthesis.

Description

This project aims to elucidate mechanisms that regulate co-translational formation of amyloids, which are associated with multiple human disorders and present an enormous challenge to biomedical science. The research seeks fundamental knowledge about cellular processes to provide a foundation for developing strategies for prevention or treatment of protein misfolding disorders. The objective is to determine the contributions of cotranslational events in functional and pathological conformational switching of nascent chains and the impact on gene expression of switching of a prion-forming protein.

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