Award
National Institute of Allergy and Infectious Diseases 5R01AI107779-10
Chromosome 17q21, allergic inflammation, and remodeling
Recipient
University of California, San Diego
Award Amount
$558,606.00
Ceiling
$558,606.00
Awarded
February 28, 2024
Identifier
5R01AI107779-10
Research project funded to study the role of ORMDL3 gene in asthma development and allergic inflammation, using transgenic mice and molecular biology techniques to identify mechanisms and potential therapeutic targets.
Description
This project focuses on the gene ORMDL3 on chromosome 17q21, linked to human asthma. It aims to understand how ORMDL3 influences CD4+ T cell function, allergic inflammation, and asthma by generating transgenic mice and investigating downstream pathways using proteomic and RNA sequencing approaches. The study also explores SNPs linked to ORMDL3 using single base editing.