Award
NIH Reporter #5U54CA274507-03
Core 2: Ecological Core
Recipient
H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States
Award Amount
$325,419.00
Ceiling
$325,419.00
Awarded
September 11, 2025
Identifier
5U54CA274507-03
Recent advances in spatial ‘omics’ have increased interest in studying tumor-immune microenvironment interactions. The Core will develop spatial ecological models, manage high-dimensional histology images, and support NSCLC projects to understand tumor heterogeneity and guide therapies.
Description
The Ecological Analysis Core will support the generation, investigation, and application of spatial ecological models and techniques to support two non-small cell lung cancer (NSCLC)-focused projects. It will manage, visualize, store, share, and analyze high-dimensional, high-resolution clinical and experimental histology images. The Core will develop computational approaches and frameworks to improve understanding and prediction of tumor behavior using images. It will develop and apply spatial ecological models alongside mathematical models from the Mathematical Modeling Core to understand tumor heterogeneity and guide new therapeutic strategies for lung cancer.