Award
National Institute of Allergy and Infectious Diseases 5R21AI178424-02
A non-canonical role of Caspase-1 in regulating bacterial antimicrobial resistance
Recipient
Institute for Systems Biology
Award Amount
$235,000.00
Ceiling
$235,000.00
Awarded
August 06, 2025
Identifier
5R21AI178424-02
The award funds research investigating how Caspase-1 regulates bacterial antimicrobial resistance by inhibiting the PhoPQ system in Salmonella, independent of its protease activity, to better understand host-pathogen interactions and combat AMR.
Description
This project explores the non-canonical, activity-independent role of Caspase-1 in controlling bacterial signaling and antimicrobial resistance (AMR). It aims to dissect the molecular mechanisms by which Caspase-1 inhibits PhoPQ activation and CAMP resistance in intracellular Salmonella, potentially revealing new therapeutic targets to combat AMR.