Award
NIH Reporter #5F31DK139666-02
Targeting cDC1 with CAR T cells to investigate their role and potential as a therapeutic target in Type 1 diabetes
Recipient
Washington University, Saint Louis, MO, United States
Award Amount
$35,187.00
Ceiling
$35,187.00
Awarded
August 15, 2025
Identifier
5F31DK139666-02
This award funds research to develop CAR T cell therapy targeting cDC1 dendritic cells to prevent Type 1 diabetes, focusing on therapy specificity, durability, and disease impact.
Description
The project aims to develop a chimeric antigen receptor (CAR) T cell therapy targeting XCR1, a chemokine receptor expressed by cDC1 dendritic cells, to prevent Type 1 diabetes in NOD mice. The study will validate the specificity of the CAR, assess the durability of cDC1 depletion, and evaluate the impact on autoimmune diabetes incidence.