Award
NIH Reporter #1R21ES037418-01A1
Placental Serotonin: A Potential Mediator of Dieldrin-Related Neurotoxicity and the Developmental Origins of Parkinson’s Disease Risk
Recipient
Rutgers Biomedical and Health Sciences, Newark, NJ, United States
Award Amount
$422,117.00
Ceiling
$422,117.00
Awarded
February 19, 2026
Identifier
1R21ES037418-01A1
This NIH grant funds research on how placental serotonin disruption by dieldrin exposure may mediate developmental neurotoxicity and increase Parkinson’s disease risk.
Description
The project investigates the role of placental serotonin (5HT) disruption as an indirect mechanism of developmental neurotoxicity caused by dieldrin, an organochlorine pesticide linked to increased Parkinson’s disease risk. It explores how developmental exposure to dieldrin affects monoamine systems in the placenta and fetal/neonatal development, potentially impacting neurodevelopmental pathways and late-life disease susceptibility.