Award
National Institute on Aging 5R01AG089455-03
Sex Dimorphism in Age-Related Knee Osteoarthritis
Recipient
Spaulding Rehabilitation Hospital
Award Amount
$574,423.00
Ceiling
$574,423.00
Awarded
June 11, 2026
Identifier
5R01AG089455-03
Research project investigating how aging and sex differences affect cartilage degradation in knee osteoarthritis, using advanced models and machine learning.
Description
This project aims to mechanistically investigate the role of soluble and physical microenvironmental factors on the loss of cartilage integrity with aging and sex differences. The research will utilize innovative approaches including biofluid exchange models, network medicine with machine learning, and a chemically-induced menopause model in mice.