Award
NIH Reporter #1R21AR086419-01A1
Targeted Drug Delivery Systems to Regenerate Muscle-Bone Composite Tissue Injuries
Recipient
University of Oregon
Award Amount
$333,508.00
Ceiling
$333,508.00
Awarded
September 04, 2026
Identifier
1R21AR086419-01A1
Research project funded by NIAMS to develop targeted nanoparticle drug delivery systems for regenerating muscle-bone composite tissue injuries, aiming to improve healing and functional restoration.
Description
This project aims to investigate the potential of targeted nanoparticle drug delivery technology as a minimally invasive treatment to accelerate the regeneration of composite injuries involving bone and muscle. These injuries, often resulting from motor vehicle accidents, industrial accidents, and blast wounds, lead to long-term impairments and significant economic burden. The study focuses on nanoparticle systems functionalized with TRAP-binding peptides to target TRAP+ cells in vitro and in vivo, promoting healing through delivery of Wnt agonist AR28 and modulation of macrophage phenotypes.