Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK127800-05
Cross-regulation of Immunometabolism and Circadian Pathways in Obesity Pathophysiology
Recipient
Northwestern University
Award Amount
$434,149.00
Ceiling
$434,149.00
Awarded
April 09, 2025
Identifier
5R01DK127800-05
This NIH-funded project investigates how circadian rhythms regulate adipose tissue metabolism and obesity, focusing on the circadian clock gene BMAL1 and its impact on metabolic health under high-fat diet conditions.
Description
The project addresses the epidemic of obesity and its relation to circadian disruption, focusing on how time-of-day influences adipose tissue metabolism and obesity outcomes. It aims to elucidate mechanisms by which circadian clocks regulate nutrient handling and energy flux in visceral adipose tissue, especially under high-fat diet conditions.