NIH Reporter #1F32EY038052-01A1

Targeting distinct neuron types in the degenerating retina for vision restoration

This award funds research to develop a retinal implant that restores vision by targeting surviving retinal cells in degenerative diseases, combining computational and electrophysiological methods with interdisciplinary training.

Description

The project aims to study how the surviving output cells of the retina, retinal ganglion cells, change during degeneration to enable tracking and control using an electronic retinal implant capable of restoring high-resolution vision to blind individuals. It involves developing computational approaches for cell type identification and conducting ex vivo electrophysiology experiments using large-scale multielectrode arrays. The research will be conducted using rat models of retinal degeneration and includes training in electrophysiology, neuroscience, machine learning, and scientific communication. The project aims to develop a future cell type-specific retinal implant for vision restoration.

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