# NIH Reporter #2R01HD104672-06

Proton-secreting epithelial cells as key modulators of epididymal mucosal immunity

**Recipient:** Massachusetts General Hospital, Boston, MA, United States

**Award Amount:** $643,333.00
**Ceiling:** $643,333.00

**Awarded:** September 11, 2026

**Identifier:** 2R01HD104672-06

Research project funded by NICHD to study proton-secreting epithelial cells in the epididymis to improve male infertility treatments and develop male contraceptives.

### Description

This project aims to advance treatments for male infertility and identify new targets for male contraception by studying the role of proton-secreting epithelial cells in the epididymis. The research focuses on understanding how these cells maintain immune privilege and regulate immune responses to protect sperm from autoimmunity and pathogens.

[View original record](https://reporter.nih.gov/search/IgE1H2ioLUOz0qmA4MDg0Q/project-details/11295592)