Award
National Institute of Diabetes and Digestive and Kidney Diseases 5F31DK141247-02
Leveraging in vivo protein tracking to identify novel immune markers associated with obesity driven disease
Recipient
SCRIPPS RESEARCH INSTITUTE, THE
Award Amount
$34,114.00
Ceiling
$34,114.00
Awarded
June 01, 2026
Identifier
5F31DK141247-02
This NIH grant funds research to identify and study proteins secreted by the intestine that influence immune cells in adipose tissue during obesity, aiming to find new therapeutic targets for obesity-related metabolic diseases.
Description
The project aims to study how obesity impacts intestinal protein secretion and how these secreted proteins affect adipose tissue immune cells during obesity development. Using a Cre-inducible biotin-ligase BirA*G3 affinity tracking system in mice, the research will identify proteins trafficked from the intestine to adipose tissue, focusing on PlexinB2. The study will validate the role of these proteins in immune cell function and obesity-related metabolic diseases, with the goal of developing targeted therapeutics.