Award
NIH Reporter #5R01CA248393-05
Development of microRNA (miR)-based cell-targeted polymeric nanoparticles for myeloma therapy
Recipient
National Cancer Institute (NCI)
Award Amount
$550,877.00
Ceiling
$550,877.00
Awarded
March 12, 2025
Identifier
5R01CA248393-05
NIH-funded research project developing miR-based polymeric nanoparticles for targeted multiple myeloma therapy, focusing on novel miR roles and therapeutic delivery methods to improve patient outcomes.
Description
This project proposes to utilize nanomedicine and non-toxic polymeric nanoparticles (NPs) to deliver microRNAs (miRs) to myeloma cells, aiming to uncover new targets and develop miR-based therapies for multiple myeloma, an incurable hematologic cancer. The study involves identifying roles of specific miRs in disease progression, exploring polymer-encapsulated miRs for therapy, and assessing effects on immune cells and macrophage polarization using cell lines, patient-derived cells, and mouse models.