Award
National Institute of Neurological Disorders and Stroke 5R01NS130126-04
Towards a biophysical model of human cortical neurophysiological signatures that incorporates cellular and cell type biophysics, transcriptomics, and morphology
Recipient
Cedars-Sinai Medical Center, Los Angeles, CA, United States
Award Amount
$557,654.00
Ceiling
$557,654.00
Awarded
June 19, 2026
Identifier
5R01NS130126-04
This research develops computational models linking gene expression, morphology, and physiology of neurons, connecting them into circuits, and simulating signals. It investigates the role of Ih currents in cortical processing, testing hypotheses through perturbations in models.
Description
The project aims to develop a biophysical model of human cortical neurophysiological signatures, integrating cellular and cell type biophysics, transcriptomics, and morphology. It involves building computational models of human neocortical neurons, connecting them into circuits, and simulating neurophysiological signals to understand cortical function.