Award
NIH Reporter #5R35GM157370-03
Deciphering Novel Principles of Rapid Proteostatic Control and Innovating Spatiotemporal Lysosomal Tools
Recipient
University of California-Irvine
Award Amount
$379,063.00
Ceiling
$379,063.00
Awarded
August 26, 2026
Identifier
5R35GM157370-03
This award funds research to uncover new mechanisms of lysosomal protein degradation and develop innovative tools for controlling protein levels in cells, with a focus on methylation-driven lysosomal delivery pathways.
Description
The project aims to understand lysosomal protein delivery mechanisms and develop tools for protein control in biological research. The research involves defining novel substrates, understanding methyl-driven delivery, and creating new tools for protein depletion. It focuses on methyl-driven lysosomal proteolysis as a widespread process enabling natural protein turnover and rapid protein remodeling in response to stimuli.