Award
National Institute on Aging 1R21AG095557-01
Targeting LARP6 in aging-associated heart failure
Recipient
University of Missouri-Columbia
Award Amount
$429,394.00
Ceiling
$429,394.00
Awarded
December 12, 2025
Identifier
1R21AG095557-01
This NIH-funded project by University of Missouri-Columbia aims to develop therapies targeting LARP6 to treat aging-associated heart failure by reducing cardiac fibrosis and improving vascularity.
Description
The project investigates the role of LARP6 in cardiac fibrosis and vasculogenic signaling, aiming to develop targeted therapies to mitigate fibrosis and enhance vascularity in aging-associated heart failure with preserved ejection fraction (HFpEF). The study uses a 'three-hit' mouse model to evaluate therapeutic potential of targeting LARP6-collagen interaction and LARP6-Vegfa manipulation.