Award
NIH Reporter #5R35GM143053-06
Reinforcing the barrier: Understanding how cell envelope modifications promote intrinsic antimicrobial tolerance and resistance in Acinetobacter baumannii
Recipient
University of Texas Dallas, Richardson, TX
Award Amount
$390,000.00
Ceiling
$390,000.00
Awarded
April 07, 2025
Identifier
5R35GM143053-06
The award supports research to understand intrinsic antimicrobial resistance mechanisms in Acinetobacter baumannii by studying cell envelope modifications, aiming to inform new drug development and treatment protocols.
Description
This project aims to understand how cell envelope modifications promote antimicrobial tolerance and resistance in Acinetobacter baumannii. It explores the relationship between peptidoglycan and outer membrane assembly, which is poorly understood in Gram-negative bacteria. Findings will help build a model of intrinsic factors leading to multidrug resistance and assist in designing drug regimens targeting both layers to prevent resistance.