Award
National Institute of Allergy and Infectious Diseases 5R21AI176055-02
CD14 collaborates with TRIF to mediate septic responses downstream of TNF receptors
Recipient
Tufts University Boston
Award Amount
$240,075.00
Ceiling
$240,075.00
Awarded
November 05, 2024
Identifier
5R21AI176055-02
The NIH grant supports research on the role of CD14 in mediating septic responses through interaction with TNF receptors, aiming to uncover mechanisms that could lead to new treatments for sepsis and inflammatory diseases.
Description
This project aims to evaluate the hypothesized link between CD14 and TNFα/TNFR1 complexes and determine whether CD14 promotes sepsis via cell-intrinsic signaling in myeloid and stromal tissues. The research focuses on understanding the role of CD14 in septic responses and its interaction with TNFα/TNFR1 complexes to identify potential mechanisms for therapeutic intervention in sepsis and related inflammatory conditions.