Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK120921-08
Photoresponsive materials to study matricellular signaling dynamics during crypt formation and fission
Recipient
University of Colorado, Boulder, CO, United States
Award Amount
$530,289.00
Ceiling
$530,289.00
Awarded
April 09, 2026
Identifier
5R01DK120921-08
This award funds research to create a model for studying intestinal crypt formation and fission, which are critical for intestinal health and regeneration, using innovative photoresponsive materials.
Description
The project aims to develop an in vitro intestinal organoid model to study the dynamics of crypt formation and fission during injury and repair, using photoresponsive hydrogels to culture intestinal organoids and investigate the role of cell-matrix interactions and crypt cell composition in crypt fission.