Award
National Cancer Institute 4R01CA281294-03
The Role of CD3z ITAM (Immunoreceptor Tyrosine-Based Activation Motif) diversity in CAR T cell Force and Function
Recipient
Utah State Higher Education System--University of Utah, Salt Lake City, UT
Award Amount
$1,739,572.00
Ceiling
$1,739,572.00
Awarded
June 26, 2026
Identifier
4R01CA281294-03
Research project funded by the National Cancer Institute to study the impact of ITAM diversity in CAR T cells on their function and therapeutic potential.
Description
This project investigates how the diversity of ITAM sequences in the CD3 zeta chain affects CAR T cell function, signaling, and tumor killing ability. The study explores the mechanosensing role of CARs and aims to optimize CAR design for improved therapeutic efficacy.