Award
NIH Reporter #5P01AI179409-03
Project 1 Mechanistic Project
Recipient
University of Florida, Gainesville, FL, United States
Award Amount
$384,945.00
Ceiling
$384,945.00
Awarded
July 14, 2026
Identifier
5P01AI179409-03
NIH grant awarded to University of Florida for research on novel antibiotics targeting bacterial superbugs resistant to carbapenem, using biochemical and modeling methods.
Description
This project addresses the urgent threat of bacterial superbugs Acinetobacter baumannii and Klebsiella pneumoniae, listed as 'Urgent' by CDC. It aims to develop novel antibiotics and combination strategies targeting penicillin-binding proteins (PBPs) to combat carbapenem-resistant strains. The research involves biochemical, molecular, and mathematical modeling approaches to optimize antibiotic combinations for high bacterial densities, including persisters.